Prescription Drug Index
SPIRONOLACTONE
This is a Generic Prescription Drug
Spironolactone
Pronounced: speer-on-oh-lak-tone
Other Name(s): Aldactone
Spironolactone flushes excess salt and water from the body and controls high blood pressure. It is used in the diagnosis and treatment of hyperaldosteronism a condition in which the adrenal gland secretes too much aldosterone (a hormone that regulates the body’s salt and potassium levels). It is also used in treating other conditions that require the elimination of excess fluid from the body. These conditions include congestive heart failure high blood pressure cirrhosis of the liver kidney disease and unusually low potassium levels in the blood. When used for high blood pressure Spironolactone can be taken alone or with other high blood pressure medications.
* Spironolactone has caused tumors in laboratory animals. Talk to your doctor about the risks and benefits of using this medicine for your condition.
ADULTS
Primary Hyperaldosteronism
Initial dosages of this medication are used to determine the presence of primary hyperaldosteronism (too much secretion of the adrenal hormone aldosterone). People can be tested with this medication over either a long or a short period of time.
In the long test 400 milligrams is taken daily for 3 to 4 weeks. If your potassium levels and blood pressure are corrected with this dosage in this time period your physician may assume you have this condition.
In the short test 400 milligrams is taken daily for 4 days. A laboratory test compares potassium levels while you are on Spironolactone and after the medication is stopped. Your doctor may then make a diagnosis.
After the diagnosis of primary hyperaldosteronism is made and confirmed by more tests the usual dose is 100 to 400 milligrams per day prior to surgery. In those who are not good candidates for surgery this drug is given over the long term at the lowest effective dose.
Fluid Retention (Congestive Heart Failure Cirrhosis of the Liver or Kidney Disorders)
The usual starting dosage is 100 milligrams daily either in a single dose or divided into smaller doses. However your doctor may have you take daily doses as low as 25 milligrams or as high as 200 milligrams.
Your doctor may choose to adjust your dosage after an initial 5-day trial period or add another diuretic medication to this one.
Essential Hypertension (High Blood Pressure)
The usual starting dosage is 50 to 100 milligrams daily in a single dose or divided into smaller doses. This medication may be given with another diuretic or with other high blood pressure medications.
It may be up to 2 weeks before the full effect of this medication is seen. Your doctor can then adjust the dosage according to your response.
Hypokalemia (Potassium Loss)
Your doctor may have you take daily dosages of 25 milligrams to 100 milligrams when potassium loss caused by the effects of a diuretic cannot be treated by a potassium supplement.
Note:
The content in this section is provided for informational purposes only. This information regarding the following Canadian drugs is not intended to replace or act as a substitute for information or advice provided by your physician. You should always consult a physician before beginning a new medication. Moreover, prescription drugs should only be obtained with a doctor's prescription.
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